Discovery of how Taxol works could lead to better anticancer drugs - Berkeley News
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Discovery of how Taxol works could lead to better anticancer drugs - B…
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Discovery of how Taxol works could lead to better anticancer drugs
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The drug Taxol, extracted from the bark of yew trees, has an opposite effect to the drug colchicine, an alkaloid from autumn crocus. Taxol binds tightly to microtubules and stabilizes them; when added to cells, it causes much of the free tubulin to assemble into microtubules. In contrast, colchicine prevents microtubule formation. Taxol is just as pernicious to dividing cells as colchicine, and both are used as anticancer drugs. Based on your knowledge of microtubule dynamics, suggest why both d
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