Screen like an icon. Colonoscopy performance based on a USPSTF review. Cologuard Plus™ performance based on FDA-approved labeling. No head-to-head analysis was performed. The Cologuard Plus test is intended to screen adults 45 and older at average risk for colorectal cancer. Do not use a Cologuard Plus test if you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. The Cologuard Plus test is not a replacement