More formally, it is an ATP -dependent efflux pump with broad substrate specificity. It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances.

P-Glycoprotein - an overview | ScienceDirect Topics

Jul 26, 2025 · P-glycoprotein, often shortened to P-gp, is a protein found in human cell membranes. It functions as a specialized “pump” that actively moves substances, pushing compounds out of cells.

P-glycoprotein, shown here from PDB entry 3g61 , is the most common molecular pump protecting our cells from toxic molecules. It sits in the cell membrane and searches for foreign hydrophobic molecules.

Oct 26, 2020 · P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP) binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to …

Jun 19, 2025 · What is P-glycoprotein? P-glycoprotein (P-gp) is a transmembrane protein that plays a crucial role in the transport of various substrates across cellular membranes.

P-glycoprotein; Multidrug resistance; Multidrug transporters; Phospholipid bilayer; Blood-brain barrier.

P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell’s apical surface, being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are compounds that can …

Jan 1, 2022 · P-glycoprotein (PGP) is a member of the adenosine triphosphate binding cassette (ABC) transporter family. It has affinity for a broad range of lipid-soluble substrates, including many …

P-glycoprotein is a protein that is involved in the transportation of active compounds from the brain to the bloodstream, protecting the central nervous system from harmful substances, and …