CYSTINE-STORAGE disease (cystinosis or Lignac-> Fanconi disease) is an uncommon but intriguing disorder, the etiology and pathogenesis of which are unknown. The cardinal pathological finding is the ...

Cystine stones are a type of kidney stone. They are also called renal calculi, nephrolithiasis, or urolithiasis, and they are caused by a genetic condition. Here’s what to know about cystine crystals ...

Using molecules that closely mimic the structure of the dimeric amino acid L-cystine, chemists have discovered a way to suppress formation of large L-cystine crystals. The finding, reported in Science ...

Cystine Stones contain cystine, a product of the amino acids cysteine and methionine. Amino acids are the building blocks of proteins. Thus the simplest way to reduce the amount of cystine in the body ...

The ability of cystine dimethylester (CDME) to load lysosomes with cystine has been used to establish the basic defect in cystinosis: defective cystine exodus from lysosomes. Using CDME loading, it ...

Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current ...

CYSTARAN (cysteamine) 0.44% ophthalmic solution Cystaran (cysteamine ophthalmic solution; Sigma-Tau) is the first FDA-approved therapy for the treatment of corneal cystine crystal accumulation in ...

It has previously been reported that cystinuria, as it appears clinically, represents at least three biochemically and genetically distinct diseases. 13 The present studies were undertaken to ...

Peptides as therapeutics are advantageous since they are generally safe and well tolerated, with a short half-life limiting risk for off-target toxicities. However, because of their small size, most ...

Use of DPC-4 immunostaining of diagnostic cytology specimens to predict the pattern of tumor progression in locally advanced pancreatic cancer patients (LAPC). Background: The plasma membrane xCT ...

Cystinuria is an inherited health condition that involves the excretion of excess cystine and other dibasic amino acids in the urine. Although cystinuria itself doesn’t cause noticeable symptoms, the ...

In vitro, in vivo studies show lack of GSH makes drug-resistant CLL sensitive to chemotherapy. Scientists say blocking bone marrow stromal cells from converting cystine into cysteine may provide a ...